Applications

CIVO™ Technology Applications

CIVO™ can be used to evaluate investigational compounds and approved therapeutics in the following areas:

Drug Development

Drug Combinations: One drug can be tested in combination with up to seven other drugs in a single tumor to evaluate how each pairing affects tumor biology and which combinations are most effective, all without first having to establish systemic dosing levels that will be well tolerated.

Single Agent Efficacy: Multiple individual drugs can be tested at the same time to measure and directly compare local response to each agent in a variety of tumor contexts.  Data obtained can comprise apoptotic signals, pathway specific pharmacodynamic markers, immune cell infiltrate and activity, as well as microenvironment markers such as hypoxia and cell clearance.